Journal of Heterocyclic Chemistry p. 1337 - 1340 (1993)
Update date:2022-08-04
Topics:
Cignarella
Villa
Barlocco
A new series of N-substituted-3-[1-alkyl(aryl)-4-piperidyl]azetidin-2- ones 2a-j structurally related to the previously reported 2,7- diazaspiro[3,5]nonan-1-ones 1 have been synthesized and tested for their activity as muscarinic agents, both in vitro and in vivo. Preliminary pharmacological results showed that compounds 2 are devoid of significant cholinergic properties.
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