Development of novel benzomorpholine class of diacylglycerol acyltransferase i inhibitors

DOI: 10.1021/ml400527n

Source and publish data:

ACS Medicinal Chemistry Letters p. 544 - 549 (2014)

Update date:2022-08-05

Topics:

Authors:

Zhou, Gang

Zorn, Nicolas

Ting, Pauline

Aslanian, Robert

Lin, Mingxiang

Cook, John

Lachowicz, Jean

Lin, Albert

Smith, Michelle

Hwa, Joyce

Van Heek, Margaret

Walker, Scott

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Article abstract of DOI:10.1021/ml400527n

Diacylglycerol acyltransferase 1 (DGAT1) presents itself as a potential therapeutic target for obesity and diabetes for its important role in triglyceride biosynthesis. Herein we report the rational design of a novel class of DGAT1 inhibitors featuring a

Full text of DOI:10.1021/ml400527n

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