Piperidinyl-nicotinamides as potent and selective somatostatin receptor subtype 5 antagonists

DOI: 10.1016/j.bmcl.2010.06.026

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Bioorganic and Medicinal Chemistry Letters p. 4521 - 4525 (2010)

Update date:2022-09-26

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Authors:

Alker, Andre

Binggeli, Alfred

Christ, Andreas D.

Green, Luke

Maerki, Hans Peter

Martin, Rainer E.

Mohr, Peter

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Article abstract of DOI:10.1016/j.bmcl.2010.06.026

Nicotinamides of benzyl-substituted 4-aminopiperidines and their seven-membered analogs of generic structure 2 and 2′ have been discovered as potent and selective SST5 antagonists. The activity (K_i) ranges from 2.4 to 436 nM. Most compounds exh

Full text of DOI:10.1016/j.bmcl.2010.06.026

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