Synthesis of taxoids 3. A novel and efficient method for preparation of taxoids by employing cis-glycidic acid

Article abstract of DOI:10.1016/S0040-4039(98)01124-1

A novel route for the synthesis of docetaxel (2) using esterification of (2R,3R)-glycidic acid with 7,10-bis-O-(2,2,2-trichloroethoxycarbonyl)-10- deacetylbaccatin III is described. Subsequent stereo- and regio-selective conversion afforded 2 and related novel compounds.