Discovery of novel, orally available benzimidazoles as melanin concentrating hormone receptor 1 (MCHR1) antagonists

DOI: 10.1016/j.bmcl.2010.07.086

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 5443 - 5448 (2010)

Update date:2022-08-03

Topics:

Authors:

Sasmal, Pradip K.

Sasmal, Sanjita

Rao, P. Tirumala

Venkatesham

Roshaiah

Abbineni, Chandrasekhar

Khanna, Ish

Jadhav, Vikram P.

Suresh Suresh

Talwar, Rashmi

Muzeeb, Syed

Receveur, Jean-Marie

Frimurer, Thomas M.

Rist, ?ystein

Elster, Lisbeth

H?gberg, Thomas

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Article abstract of DOI:10.1016/j.bmcl.2010.07.086

Melanin concentrating hormone (MCH) is an important mediator of energy homeostasis and plays role in several disorders such as obesity, stress, depression and anxiety. The synthesis and biological evaluation of novel benzimidazole derivatives as MCHR1 antagonists are described. The in vivo proof of principle for weight loss with a lead compound from this series is exemplified.

Full text of DOI:10.1016/j.bmcl.2010.07.086

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