3,4-Diarylpiperidines as potent renin inhibitors

DOI: 10.1016/j.bmcl.2012.01.044

Source and publish data:

Bioorganic and Medicinal Chemistry Letters p. 1953 - 1957 (2012)

Update date:2022-09-26

Topics:

Authors:

Lacombe, Patrick

Arbour, Mélissa

Aspiotis, Renée

Cauchon, Elizabeth

Chen, Austin

Dubé, Daniel

Falgueyret, Jean-Pierre

Fournier, Pierre-André

Gallant, Michel

Grimm, Erich

Han, Yongxin

Juteau, Hélne

Liu, Suzanna

Mellon, Christophe

Ramtohul, Yeeman

Simard, Daniel

St-Jacques, René

Tsui, Gavin Chit

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Article abstract of DOI:10.1016/j.bmcl.2012.01.044

The discovery and SAR of a series of potent renin inhibitors possessing a novel 3,4-diarylpiperidine scaffold are described herein. The resulting compound 38 exhibit low nanomolar plasma renin IC₅₀, had a clean CYP 3A4 profile and displayed mic

Full text of DOI:10.1016/j.bmcl.2012.01.044

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