Improved preparation of (R) and (S)-3-aminoquinuclidine dihydrochloride

Article abstract of DOI:10.1080/00397919608003556

An improved procedure for the synthesis of either (R) or (S)-3-aminoquinuclidine was developed. Key intermediate imine 2 was made in a one pot process using lithium oxide as the base and molecular sieves.

Full text of DOI:10.1080/00397919608003556

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Synthetic Communications: An
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Organic Chemistry
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Improved Preparation of (R)
and (S)-3-Aminoquinuclidine
Dihydrochloride
Bruce A. Kowalczyk a , John C. Rohloff a , Charles A.
Dvorak a & John O. Gardner a
a Chemical Development, Syntex Research, Palo
Alto, California, 94304
Version of record first published: 21 Aug 2006.
To cite this article: Bruce A. Kowalczyk , John C. Rohloff , Charles A. Dvorak &
John O. Gardner (1996): Improved Preparation of (R) and (S)-3-Aminoquinuclidine
Dihydrochloride, Synthetic Communications: An International Journal for Rapid
Communication of Synthetic Organic Chemistry, 26:10, 2009-2015
To link to this article: http://dx.doi.org/10.1080/00397919608003556
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