STEREOCONTROLLED TOTAL SYNTHESIS OF THE PENICILLINATE ESTER (2S,5R)-BENZYL 3,3-DIMETHYL-7-OXO-4-THIA-1-AZABICYCLOHEPTANE-2-CARBOXYLATE

Article abstract of DOI:10.1016/S0040-4039(01)80395-6

(3R)-4-Acetoxy-3-trimethylsilyl-2-azetidinone, was converted into optically pure benzyl penicillinate in seven step (22percent) using (benzyloxy)nitromethane as a reagent for ring annulation.