European Journal of Medicinal Chemistry p. 471 - 474 (1989)
Update date:2022-07-29
Topics:
Pouillart, Philippe
Ronco, Gino
Pieri, Francois
Brazier, Michel
Villa, Pierre
Synthesis of four glucose and galactose mono- and poly- butyric esters was carried out.A preliminary toxicologic and pharmacokinetic study showed that it was possible to utilise these new molecules and allows an estimation to be made of their seric half-life in animals.The results obtained show it is possible to maintain large seric potential n-butyric acid concentrations.The first tests performed on experimental animals with tumors treated by these esters show a survival increase similar to that with butyric salts. n-butyric acid/butyric ester/glucose ester/galactose ester/prolonged effect
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