Synthesis of the Pyrroloisoquinoline Substructure of the Manzamine Family of Alkaloids

DOI: 10.1016/S0040-4039(00)99077-4

Source and publish data:

Tetrahedron Letters p. 2611 - 2614 (1989)

Update date:2022-08-02

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Authors:

Hart, David J.

McKinney, Jeffrey A.

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Article abstract of DOI:10.1016/S0040-4039(00)99077-4

The first synthesis of the tricyclic pyrrolo<2,3-i>isoquinoline substructure of manzamines A, B, E and F is described.Reductive alkylation of benzoic acid followed by a 3-aza-6-heptenyl radical cyclization gave octahydroisoquinoline 9.An electrophile init

Full text of DOI:10.1016/S0040-4039(00)99077-4

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