PRACTICAL SYNTHESIS OF (+)-9(O)-METHANO-Δ6(9α)-PGI1. THE HIGHLY POTENT CARBON ANALOG OF PROSTACYCLIN

DOI: 10.1246/cl.1984.579

Source and publish data:

Chemistry Letters p. 579 - 582 (1984)

Update date:2022-08-03

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Authors:

Sodeoka, Mikiko

Shibasaki, Masakatsu

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Article abstract of DOI:10.1246/cl.1984.579

A practical synthesis of (+)-9(O)-methano-Δ^6(9α)-PGI₁, potentially a useful therapeutic agent, has been accomplished by utilizing the intramolecular aldol condensation as key step followed by the Wittig reaction and the regioselective hydrogenation.

Full text of DOI:10.1246/cl.1984.579

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