PRACTICAL SYNTHESIS OF (+)-9(O)-METHANO-Δ6(9α)-PGI1. THE HIGHLY POTENT CARBON ANALOG OF PROSTACYCLIN

Article abstract of DOI:10.1246/cl.1984.579

A practical synthesis of (+)-9(O)-methano-Δ^6(9α)-PGI₁, potentially a useful therapeutic agent, has been accomplished by utilizing the intramolecular aldol condensation as key step followed by the Wittig reaction and the regioselective hydrogenation.