Facile and efficient conjugate additions of β-dicarbonyl compounds and nitroalkanes to 4-aryl-4-oxobut-2-enoates

Article abstract of DOI:10.2298/JSC100909066L

Facile and efficient conjugate additions of carbon nucleophiles, such as β-dicarbonyl compounds and nitroalkanes, to 4-aryl-4-oxobut-2-enoates have been achieved under simple base catalysis. A variety of multi-functional γ-keto esters could be convenientl

Full text of DOI:10.2298/JSC100909066L

J. Serb. Chem. Soc. 76 (7) 947–954 (2011)
UDC 547.26’11+547.418:544.412.1
JSCS–4173
Original scientific paper
Facile and efficient conjugate additions of β-dicarbonyl
compounds and nitroalkanes to 4-aryl-4-oxobut-2-enoates
XIN LV, YAOHONG ZHANG, LIEJIN ZHOU and XIAOXIA WANG*
Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces, College of Chemistry and
Life Sciences, Zhejiang Normal University, Jinhua 321004, P. R. China
(Received 9 September 2010, revised 3 January 2011)
Abstract: Facile and efficient conjugate additions of carbon nucleophiles, such
as β-dicarbonyl compounds and nitroalkanes, to 4-aryl-4-oxobut-2-enoates
have been achieved under simple base catalysis. A variety of multi-functional
γ-keto esters could be conveniently obtained in good to excellent yields with
complete regioselectivity.
Keywords: conjugate addition; multi-functional γ-keto ester; β-dicarbonyl com-
pound; nitroalkane; 4-aryl-4-oxobut-2-enoate.
INTRODUCTION
The catalytic conjugate addition of carbon nucleophiles to electron-deficient
alkenes is one of the most important synthetic strategies for direct C–C bond for-
1–3
mation,
and many of the corresponding adducts are of great value in biolo-
4
gical chemistry and in the field of pharmaceutical.
Both β-dicarbonyl derivatives and nitroalkanes are important sources of sta-
bilized carbanions and the employment of these C-nucleophiles for conjugate ad-
4
dition has drawn much attention. The addition of β-dicarbonyl compounds to ac-
tivated carbonyl systems could afford potential precursors for a variety of biolo-
4–6
gically active substances or medicinal intermediates;
the adducts from nitroal-
kanes could be conveniently converted to amines, ketones, aldehydes, hydrides,
4,7–11
and other useful building blocks.
4-Aryl-4-oxobut-2-enoates are known as biologically and medicinally im-
12
portant small molecules. These substrates can be conveniently synthesized
12–17
from readily available and low-cost materials.
In recent years, Michael
addition reactions employing 4-aryl-4-oxobut-2-enoates as the acceptors have
been of great interest in modern chemistry, because the corresponding multi-
functionalized adducts are of potential value in synthetic or pharmaceutical
*Corresponding author. E-mail: wangxiaoxia@zjnu.cn
doi: 10.2298/JSC100909066L
947
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948
LV et al.
18–23
areas.
For example, Han developed a practical synthesis of 2-azolyl substi-
18
tuted 4-oxo-4-arylbutanoates using azoles as the nucleophiles. The conjugate
addition between indoles and 4-aryl-4-oxobut-2-enoates facilitated by a Lewis
acid was recently found.
20
The addition of 1,3-dicarbonyl compounds to 4-aryl-4-oxobut-2-enoates
could afford various synthetically or medicinally useful multi-carbonyl derivati-
ves. For example, Tan et al. reported bicyclic guanidines-catalyzed Michael re-
action of dimethyl malonate with fumaric derivatives, but only one example was
21
the reaction with a 4-aryl-4-oxobut-2-enoate. However, to the best of our
knowledge, no systematic study on this type of addition has been reported.
Conjugate addition reactions of nitroalkanes to 4-aryl-4-oxobut-2-enoates
7,22,23
are rare in the literature.
Xiao successfully employed a Cinchona alkaloid-
-based thiourea catalyst for the Michael addition of nitroalkanes to 4-oxo-2-eno-
7
ates. Tishkov et al. reported the 1,8-diazabicyclo[5.4.0]undec-7-ene (DBU)-ca-
22
talyzed addition of nitromethane to methyl 4-phenyl-4-oxobut-2-enoate. Feng
and coworkers recently reported that a chiral N,N’-dioxide-Sc(OTf) complex
3
worked well for Michael additions of β-dicarbonyl compounds and nitromethane
23
to 4-aryl-4-oxobut-2-enoates. However, to the best of our knowledge, β-keto
esters have not been employed as the C-nucleophiles for conjugate addition with
4-oxo-2-enoates.
Other approaches to these multi-functional γ-keto esters have also been de-
veloped. For example, Smirnov et al. reported that the reactions of 3-bromo-3-
-nitroacrylates with 2-phenyl-1,3-indanedione under the catalysis of triethyl-
amine (TEA) could afford 2-[1-(alkoxycarbonyl)-2-nitroethyl]-2-phenyl-1,3-in-
24
danediones. Ballini and coworkers found that polyfunctionalized nitroalkanes
could be synthesized from the addition of active methylene compounds to β-
25
nitroacrylates. They also synthesized multi-functional β-nitro esters using β-
26
nitroacrylates and silyl enol ethers as the starting materials.
However, in spite of these developments, the previously described methods
might suffer from harsh conditions (such as low temperatures), poor yields, nar-
row scopes, expensive (or special) catalysts, and/or tedious procedures. There-
fore, more convenient, versatile and efficient strategies for the synthesis of multi-
-functional γ-keto esters derived from 4-aryl-4-oxobut-2-enoates are still in de-
mand (Fig. 1).
Herein, as a continuation of ongoing studies on catalytic conjugate additions
employing 4-aryl-4-oxobut-2-enoates as strategic starting materials, the conju-
gate addition of various β-dicarbonyl compounds or nitroalkanes to 4-aryl-4-
-oxobut-2-enoates using a common inorganic base catalyst is presented as a fa-
cile protocol to generate multi-functionalized γ-keto esters with complete regio-
selectivity and high efficiency.
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ADDITIONS OF C-NUCLEOPHILES TO 4-ARYL-4-OXOBUT-2-ENOATES
949
Fig. 1. Recently reported catalytic conjugate addition reactions of 4-aryl-4-oxobut-2-enoates
with β-dicarbonyl compounds and nitroalkanes.
RESULTS AND DISCUSSION
Initially, the work focused on the catalytic conjugate addition of methyl ace-
toacetate 1a to ethyl 4-phenyl-4-oxobut-2-enoate 2a. In the first attempt perfor-
med in tetrahydrofuran, THF, with Et N (20 mol %) as the catalyst at room tem-
3
perature, the desired product 3a was obtained but in unsatisfactory yield (Scheme 1,
Table I). Then, attempts were made to optimize the reaction conditions. Evident-
ly, the key point in the reaction is the choice of solvent. Various solvents (THF,
benzene, CH CN, Et O, CH Cl , and EtOH) were examined and the result was
3
2
2
2
remarkably improved when EtOH was used as the solvent. After screening a
range of bases (Et N, pyridine, KOH, 1,4-diazabicyclo[2.2.2]octane (DABCO),
3
DBU and t-BuOK), the weak inorganic base K CO was found to be the optimal
2
3
base to promote the conjugate addition.
O
O
O
OMe
OEt
Me
O
O
O
O
Catalyst (20 mol%)
Solvent, reflux
OEt
Ph
Me
OMe
Ph
O
3a
1a
2a
Scheme 1. The catalytic conjugate addition of methyl acetoacetate to
ethyl 4-phenyl-4-oxobut-2-enoate.
Under the optimized conditions, various β-dicarbonyl derivatives and 4-aryl-
-4-oxobut-2-enoates were employed as the substrates to test the generality of the
reaction (Scheme 2, Table II). Both β-keto esters and malonic esters undergo the
conjugate additions smoothly to give the corresponding adducts in good to excel-
lent yields within a short reaction time (within 2.5 h). Generally, neither electron-
-donating groups (4-Me, 3,4-dimethyl) nor electron-withdrawing groups (4-Cl,
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950
LV et al.
4-Br) on the aromatic ring seemed to exert an apparent influence on the effi-
ciency of the reaction (entries 3, 5, 7, 8 and 10), although the reaction of the 4-
-aryl-4-oxobut-2-enoate bearing a strong electron-donating group, such as PhO–,
required a little longer time and gave a relatively lower yield (entries 4 and 9).
TABLE I. The catalytic conjugate addition of methyl acetoacetate to ethyl 4-phenyl-4-oxobut-
-2-enoate under different conditions
Entry
Catalysta
Solvent
Yieldb, %
1
2
3
4
5
6
7
8
Et3N
Et3N
Et3N
Et3N
Et3N
THF
PhH
CH3CN
Et2O
CH2Cl2
EtOH
EtOH
EtOH
EtOH
EtOH
EtOH
40
22
18
33
49
60
42
16
53
81
88
Et3N
Pyridine
DABCO
DBU
t-BuOK
K2CO3
9
10
11
a
b
Catalyst load: 20 mol %; isolated yields, the runs were performed under reflux conditions for 2.5 h
O
O
O
R1
O
O
OR2
OR3
O
O
K2CO3 (20 mol %)
EtOH, reflux
OR3
R1
OR2
Ar
Ar
O
1
2
3
Scheme 2. K2CO3 catalyzed Michael addition of 1,3-dicarbonyl compounds to
4-aryl-4-oxobut-2-enoates.
TABLE II. K2CO3 catalyzed Michael addition of 1,3-dicarbonyl compounds to 4-aryl-4-oxo-
but-2-enoates (reaction conditions: β-dicarbonyl compound 1 (1 mmol), 4-aryl-4-oxobut-2-
-enoate 2 (1 mmol) in EtOH (10 mL) with K2CO3 (0.2 mmol, 20 mol %) as catalyst, stirred
under reflux)
Entry
1
R1
Me
R2
Me
Ar
R3
Et
Product
Time, h
2.0
Yielda, %
3ab
88
2
3
4
5
Me
Me
Me
Me
Et
Et
Et
Et
CH2Ph
Et
3bb
3cb
3db
3eb
2.0
2.0
2.5
2.0
85
82
77
89
Br
CH2Ph
Et
PhO
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ADDITIONS OF C-NUCLEOPHILES TO 4-ARYL-4-OXOBUT-2-ENOATES
951
TABLE II. Continued
Entry
R1
R2
Ar
R3
Et
Product
Time, h
2.0
Yielda, %
6
OEt
Et
3f
90
7
8
OEt
OEt
Et
Et
Et
Et
3gb
3hb
2.5
2.0
82
86
Cl
9
OEt
OEt
Et
Et
CH2Ph
Et
3ib
3jb
2.5
2.5
81
85
PhO
10
a
b
Isolated yields; new compound
Using 4-aryl-4-oxobut-2-enoates as the acceptors, it was decided to investi-
gate the addition of other carbon nucleophiles, such as nitroalkanes. Fortunately,
it was found that the reactions could also proceed efficiently with K CO as the
2
3
catalyst (Scheme 3, Table III) and that CH Cl is a superior solvent for the reac-
2
2
tions. Various substituted 4-aryl-4-oxobut-2-enoates and nitroalkanes were em-
ployed as the substrates to examine the scope of the addition and the results are
summarized in Table III. Both nitromethane and nitroethane reacted successfully
with 4-aryl-4-oxobut-2-enoates and gave the corresponding products in good
yields at room temperature within 3 h. With regard to the substituents on the aryl
moiety in 4-aryl-4-oxobut-2-enoates, their electron properties seem to only slightly
affect the efficiency of the reactions.
R1
NO2
OR2
O
O
K2CO3 (20 mol %)
CH2Cl2, rt
OR2
R1CH2NO2
Ar
Ar
O
O
4
2
5
Scheme 3. K2CO3 catalyzed Michael addition of nitroalkanes to 4-aryl-4-oxobut-2-enoates.
TABLE III. K2CO3 catalyzed Michael addition of nitroalkanes to 4-aryl-4-oxobut-2-enoates
(reaction conditions: nitroalkane 4 (1 mmol), 4-aryl-4-oxobut-2-enoate 2 (1 mmol), in CH2Cl2
(10 mL) with K2CO3 (0.2 mmol, 20 mol %) as catalyst, stirred at room temperature
Entry
1
R1
H
Ar
R2
Et
Product
Time, h
3.0
Yielda, %
5a
81
2
3
H
H
Et
Et
5b
5c
3.0
2.0
80
86
Br
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952
LV et al.
TABLE III. Continued
Entry
R1
Ar
R2
CH2Ph
Product
5d
Time, h
2.5
Yielda, %
85
4
H
5
H
CH2Ph
CH2Ph
5eb
5fb
1.5
3.0
87
82
Cl
6
Me
a
b
Isolated yields; new compound
It is noteworthy that the above catalytic conjugate reactions exhibited com-
plete regioselectivity. The carbon nucleophiles selectively attacked the β-position
of the ketone carbonyl and no product from the addition on the β-position of the
ester carbonyl was observed under the employed catalytic conditions.
Among the results, most of the products, including all adducts (3a–e) deri-
ved from the reactions with β-keto esters, are new compounds.
EXPERIMENTAL
The employed reagents were commercially available and used without further purifi-
cation unless otherwise indicated. EtOH was treated with magnesium before distillation. 4-
-Aryl-4-oxobuten-2-oic acid,27 and the corresponding esters 2 were prepared according to lite-
rature procedures.28 TLC was performed on silica gel plates with F-254 indicator; viewing
was by UV light (254 nm). Flash column chromatography was realized over silica gel (200–
1
–300 mesh), using ethyl acetate/petroleum ether mixtures as eluents. The H- and 13C-NMR
spectra were recorded on a Bruker AVANCE 400 MHz spectrometer with CDCl3 as solvent
and TMS as the internal standard. The infrared (IR) spectra were recorded on a Nicolet Nexus
670 FT-IR spectrophotometer. The elemental analyses were performed on a Various-ELIII
elemental analyzer.
General procedure for the conjugation of β-dicarbonyl compounds 1 to 4-aryl-4-oxobut-2-
-enoates 2. Synthesis of compounds 3
To a solution of 4-aryl-4-oxobut-2-enoate 2 (1 mmol) and β-dicarbonyl compounds 1 (1
mmol) in anhydrous EtOH (10 mL) was added K2CO3 (0.2 mmol, 20 mol %) at room tempe-
rature. The mixture was stirred under reflux and monitored by TLC. After the starting material
2 had been completely consumed, the reaction mixture was cooled to room temperature and
quenched by HCl (0.03 mol L-1). The solvent was evaporated under vacuum and the residue
was extracted with ethyl acetate. The combined organic layers were washed with saturated
NaCl. Then, the organic layer was dried over anhydrous MgSO4. After solvent evaporation
under vacuum, the residue was purified by flash column chromatography on silica gel to give
the desired products 3.
General procedure for the conjugation of nitroalkanes 4 to 4-aryl-4-oxobut-2-enoates 2.
Synthesis of compounds 5
To a solution of 4-aryl-4-oxobut-2-enoate 2 (1 mmol) and nitroalkane 4 (1 mmol) in CH2Cl2
(10 mL) was added K2CO3 (0.2 mmol, 20 mol %). The mixture was stirred at room tempera-
ture and monitored by TLC. After the starting material 2 had been completely consumed, the
reaction was quenched by HCl (0.03 mol L-1). The mixture was extracted with ethyl acetate.
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ADDITIONS OF C-NUCLEOPHILES TO 4-ARYL-4-OXOBUT-2-ENOATES
953
The combined organic layers were washed with saturated NaCl and then dried over anhydrous
MgSO4. After solvent evaporation under vacuum, the residue was purified by flash column
chromatography on silica gel to give the desired products 5.
CONCLUSIONS
In summary, a facile and efficient conjugate addition of β-dicarbonyl com-
pounds and nitroalkanes to 4-aryl-4-oxobut-2-enoates was achieved. The obtain-
ed multi-functionalized adducts might be synthetically or pharmaceutically im-
portant. Compared with the reported methods using expensive or unavailable or-
ganic catalysts, a common and inexpensive inorganic base (K2CO3) was employ-
ed as the base catalyst. The presented reaction proceeded with complete regiose-
lectivity and various substituents were tolerated. In addition, the methodology
could be successfully applied to reactions with various C-nucleophiles, including
β-keto esters. The common catalyst, the ready availability of the materials, the
simplicity of the procedure and the potentially valuable adducts make the pro-
tocol potentially practical and useful to synthetic chemists.
SUPPLEMENTARY MATERIAL
Spectral data of the products are available electronically at http://www.shd.org.rs/JSCS/,
or from the corresponding author on request.
Acknowledgement. This work was financially supported by the National Natural Science
Foundation of China (No. 20802070).
И З В О Д
ЈЕДНОСТАВНА И ЕФИКАСНА КОНЈУГОВАНА АДИЦИЈА β-ДИКАРБОНИЛНИХ
ЈЕДИЊЕЊА И НИТРОАЛКАНА НА 4-АРИЛ-4-ОКСОБУТ-2-ЕНОАТЕ
XIN LV, YAOHONG ZHANG, LIEJIN ZHOU и XIAOXIA WANG
Zhejiang Key Laboratory for Reactive Chemistry on Solid Surfaces, College of Chemistry and Life Sciences,
Zhejiang Normal University, Jinhua 321004, P. R. China
Остварена је једноставна и ефикасна конјугована адиција угљеникових нуклеофила као
што су β-дикарбинилна једињења и нитроалкани на 4-арил-4-оксобут-2-еноате, у базно-ката-
лизованим реакционим условима. Под примењеним условима могу се добити различити
више-функционални γ-кето естри у добром до одличном приносу, уз потпуну региоселек-
тивност реакције.
(Примљено 9. септембра 2010, ревидирано 3. јануара 2011)
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