Acyclic purine phosphonate analogues as antiviral agents. Synthesis and structure-activity relationships

DOI: 10.1021/jm00166a019

Source and publish data:

Journal of Medicinal Chemistry p. 1207 - 1213 (1990)

Update date:2022-08-04

Topics:

Authors:

Kim Kim

Luh Luh

Misco Misco

Bronson Bronson

Hitchcock

Ghazzouli

Martin Martin

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Article abstract of DOI:10.1021/jm00166a019

A series of 9-(phosphonoalkyl)purines, which are analogues of 9-[2-(phosphonomethoxy)ethyl]purines (guanine, PMEG, 1; adenine, PMEA, 2), were synthesized. The analogues were tested for activity against herpes simplex virus types 1 and 2 (HSV-1 and HSV-2),

Full text of DOI:10.1021/jm00166a019

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