Bioorganic and Medicinal Chemistry Letters p. 5979 - 5983 (2010)
Update date:2022-08-05
Topics:
Wang, Menghua
Xia, Yi
Fan, Yuting
Rocchi, Palma
Qu, Fanqi
Iovanna, Juan L.
Peng, Ling
Novel arylethynyltriazole acyclonucleosides were synthesized and assessed for their anticancer activity on drug-resistant pancreatic cancer MiaPaCa-2 cells. One lead compound was found to have much more potent apoptosis-related antiproliferative effects than gemcitabine, the current first-line treatment for pancreatic cancer. Further investigations showed that this active compound did not inhibit DNA synthesis, which means that it does not resemble gemcitabine and may involve a different mechanism of action.
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