Molecules (2020)
Update date:2022-07-29
Topics:
Neumann, Helfried
Sergeev, Alexey G.
Spannenberg, Anke
Beller, Matthias
A flexible two-step, one-pot procedure was developed to synthesize 2-aryl propionic acids including the anti-inflammatory drugs naproxen and flurbiprofen. Optimal results were obtained in the presence of the novel ligand neoisopinocampheyldiphenylphosphine (NISPCPP) (9) which enabled the efficient sequential palladium-catalyzed Heck coupling of aryl bromides with ethylene and hydroxycarbonylation of the resulting styrenes to 2-aryl propionic acids. This cascade transformation leads with high regioselectivity to the desired products in good yields and avoids the need for additional purification steps.
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Doi:10.1515/znb-2010-0905
(2010)Doi:10.1080/07328303.2010.511749
(2010)Doi:10.1016/j.tet.2010.09.008
(2010)Doi:10.1016/j.tetlet.2010.09.095
(2010)Doi:10.1016/j.ultsonch.2014.08.004
(2015)Doi:10.1021/ic101694z
(2010)