USE OF HEXAMETHYLPHOSPHORAMIDE (HMPA) IN THE ALKYLATION OF AROMATIC AMINES: SYNTHESIS OF AZETIDINES, PYRROLIDINES, PIPERIDINES AND HEXAHYDROAZEPINES

DOI: 10.1016/0040-4020(89)80091-2

Source and publish data:

Tetrahedron p. 629 - 636 (1989)

Update date:2022-07-30

Topics:

Authors:

Juaristi, Eusebio

Madrigal, Domingo

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Article abstract of DOI:10.1016/0040-4020(89)80091-2

The direct alkylation of p-toluidine, as a model of aromatic amines, with 1,3-, 1,4-, 1,5- and 1,6-ditosylates, -dibromides or -dimesitylates in HMPA as solvent affords the corresponding cyclic amines.The convenience of this reaction and some observed lim

Full text of DOI:10.1016/0040-4020(89)80091-2

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