USE OF HEXAMETHYLPHOSPHORAMIDE (HMPA) IN THE ALKYLATION OF AROMATIC AMINES: SYNTHESIS OF AZETIDINES, PYRROLIDINES, PIPERIDINES AND HEXAHYDROAZEPINES

DOI: 10.1016/0040-4020(89)80091-2

Source and publish data:

Tetrahedron p. 629 - 636 (1989)

Update date:2022-07-30

Topics:

Authors:

Juaristi, Eusebio

Madrigal, Domingo

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1016/0040-4020(89)80091-2

The direct alkylation of p-toluidine, as a model of aromatic amines, with 1,3-, 1,4-, 1,5- and 1,6-ditosylates, -dibromides or -dimesitylates in HMPA as solvent affords the corresponding cyclic amines.The convenience of this reaction and some observed lim

Full text of DOI:10.1016/0040-4020(89)80091-2

Products guided by the article

Product name:N,N',N'',N'''-tetrakis(p-tolyl)1,5,9,13-tetraazacyclohexadecane

Cas No:125836-34-2

R&D Labs maybe for 125836-34-2

Shandong Dayi Chemical Co., Ltd.

website:http://www.dayi.com.cn

Contact:+86- 535-7388728. 15306386031

Address:No 1 Danya west road, Laiyang City, Shandong province
Jiangxi Global Natural Spice Co., Ltd.

website:https://www.jxhqxl.com/

Contact:+86-796-8106598

Address:No.89, Wenshan Road,South Industrial Park, Jishui County,Jiangxi Province
zhangjiagang bonded areas banggao co;ltd

website:http://www.shunchangchem.com

Contact:0086-13921972933

Address:Dongsha Chemical Zone.Zhangjiagang, Jiangsu Province
Nanjing Chemipioneer Pharma&Tech Co.,Ltd

website:http://www.chemipioneer.com.cn

Contact:+86-25-52685700

Address:Room 305，A Block，Biological-Medicine Building，Business Start-up Center，Xin-ke 1st Road, High-tech development zone，Nanjing city，Jiangsu Province, China
Afine Chemicals Limited

website:http://www.afinechem.com

Contact:+86-571-85134551

Address:No. 206 Zhen Hua Road, Hangzhou 310030, Zhejiang, China

Relevant to this article

Unusually large bite angle of a distally diphosphanylated calix[4]arene chelator

Doi:10.1002/ejic.201000595
(2010)
Regioselective synthesis of poly-substituted naphthalenes via a Pd-catalyzed cyclization of modified Baylis-Hillman adducts: Selective 6-endo Heck reaction and an aerobic oxidation cascade

Doi:10.1016/j.tetlet.2010.09.127
(2010)
N-Methylacridinium Salts: Carbon Lewis Acids in Frustrated Lewis Pairs for σ-Bond Activation and Catalytic Reductions

Doi:10.1002/anie.201406122
(2014)
Activation of an aryl C-H bond converts chelating diphenolate ligands bound to zirconium into trianionic pincer ligands: σ-Donor ligand effects versus thermolysis

Doi:10.1021/om100732d
(2010)
Convenient and easy access to 2-hydroxycyclopent-2-enones from acylcyanohydrins

Doi:10.1016/j.tet.2019.07.010
(2019)
Study on the reactions of 3-bromo-4-ethoxy-1,1,1-trifluoro-3-buten-2-one with benzenethiols promoted by InCl₃?4H₂O

Doi:10.1002/cjoc.201090275
(2010)

Article Doi