Highly enantioselective synthesis of (diarylmethyl)amines by rhodium-catalyzed arylation of N-nosylimines using a chiral bicyclo[3.3.0]diene ligand

Article abstract of DOI:10.1055/s-0030-1258210

A highly efficient asymmetric arylation of N-nosylimines with arylboronic acids catalyzed by a rhodium-diene complex is described. A wide range of enantiopure (98-99% ee) N-(diarylmethyl)nosylamides, as well as (3S)-2-(4-nosyl)-3-phenylisoindolin-1-one, were obtained in high yields (83-99%) under very mild conditions. Georg Thieme Verlag Stuttgart New York.