DECARBOXYLATION OF α-AMINO ACIDS BY PYRUVIC ACID AND ITS DERIVATIVES. EVIDENCE FOR AZOMETHINE YLIDES IN IN VITRO ANALOGUES OF PYRUVOYL ENZYMIC PROCESSES

Article abstract of DOI:10.1016/S0040-4039(00)99139-1

Reaction of α-amino acids with pyruvic acid, ethyl pyruvate or pyruvamide in hot DMF results in imine formation followed by decarboxylation to generate azomethine ylides stereospecifically.The azomethine ylides undergo stereospecific cycloaddition to N-me