5'-O-benzoyl-2'-keto-3'-deoxy-α-uridine: First unambiguous synthesis, crystal structure and its use to establish the anomerisation of 2'-ketouridines under basic conditions

Article abstract of DOI:10.1016/0040-4020(95)01011-4

5'-O-benzoyl-3'-deoxy-2'-keto-α-uridine was characterised unambiguously with the help of crystal structure analysis and provided ¹H-NMR data to differentiate it from its β-anomer. We have also established, with the help of the above ¹H-NMR data that the earlier reported procedures of synthesising 2'-ketouridine produced a mixture of anomers.