New 7-substituted quinolone antibacterial agents. II. The synthesis of 1-ethyl-1,4-dihydro-4-oxo-7-(pyrazolyl, isoxazolyl, and pyrimidinyl)-1,8-naphthyridine and quinolone-3-carboxylic acids

Article abstract of DOI:10.1002/jhet.5570260445

Synthetic methods for the construction of certain aromatic heterocyclic side chains for the quinolone antibacterials have been provided. In particular a series of 7-(pyrazol-3 or 4-yl, or 5-isoxazolyl and 4- or 5-pyrimidinyl)-1-ethyl-1,4-dihydro-4-oxo-1,8