Solution phase synthesis of (1→5)-amide linked sugar amino acid dimers derived from sialic acids

Article abstract of DOI:10.1016/S0040-4039(97)00138-X

Carboxy-protected amino derivatives and amino-protected carboxy derivatives of three different C-2 analogs as well as a 2,3-dehydro NeuAc were prepared. These monomers were coupled in solution using BOP activation of the carboxy terminus to form (1→5)-amide linked dimers of sialyl amino acid derivatives.