Organic Letters p. 4190 - 4195 (2020)
Update date:2022-09-26
Topics: Phosphorus(III)-Mediated Tandem Deoxygenative 1,2-Diketones
Choi, Garam
Chung, Won-Jin
Hwang, Sunjoo
Jang, Hanna
Kim, Ha Eun
Tetrasubstituted carbon containing two different halogen substituents was constructed in a single-step operation by utilizing the carbene-like reactivity of dioxaphospholene through the tandem reaction of electrophilic and nucleophilic halogenating reagents. It was crucial to devise non-dealkylatable phosphoramidite, which enabled the efficient formation of geminal chlorofluorides from various 1,2-diketones with (PhSO2)2NF and n-Bu4NCl. In addition, selective functionalization of the chlorine substituent was demonstrated, and the absence of halogen scrambling was confirmed.
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Doi:10.1039/j39670001233
(1967)Doi:10.1002/ejoc.201001165
(2011)Doi:10.1002/chem.201002563
(2010)Doi:10.1021/jo960965u
(1997)Doi:10.1248/cpb.43.241
(1995)Doi:10.1021/ol103152t
(2011)
