Nucleophilic substitution of halogen in 4-halo derivatives of glutamic acid 3. High pressure effect on the stereochemical result of the reaction

Article abstract of DOI:10.1007/BF01435778

Reactions of diastereomeric dialkyl N-phthaloyl-4-haloglutamates with para-anisidine were studied at high pressure, and an additional confirmation of the exact S_N2 mechanism of the reactions was obtained. Quantitative parameters of the relative reactivity of the diastereomers were found in various solvents, which made it possible to perform the desired synthesis of products of diastereomeric substitution.