MedChemComm p. 452 - 458 (2014)
Update date:2022-07-29
Topics:
Nishiyama, Hiroyuki
Ono, Masahiro
Sugimoto, Takuya
Sasai, Toshio
Asakawa, Naoyuki
Ueno, Satoshi
Tominaga, Yoshitaka
Yaegashi, Takashi
Nagaoka, Masato
Matsuzaki, Takeshi
Kogure, Noriyuki
Kitajima, Mariko
Takayama, Hiromitsu
A series of 4-substituted colchicine derivatives were synthesized and evaluated with an eye toward developing new anticancer agents. As a result, 4-chlorocolchicine derivatives bearing a thioureide side chain at the C-7 position were found to exhibit significant cytotoxicities to three human cancer cell lines (A549, HT-29, and HCT116). In particular, compound 26 having an ethylthioureide group at the C-7 had high antitumor activity in vivo and a broad effective dosage range. Furthermore, compound 58, which has a (5-methylpyrazol-3-yl)thioureide group at the C-7 side chain, exhibited strong cytotoxicity and desirable metabolic stability in vitro.
View MoreHangzhou Yingshanhua Pigment Chemicals Co.,Ltd.
Contact:+86-0150-58101658
Address:Nanyang Economic DevelopmentZong,Xiaoshan,Hangzhou,China
chengdu firsterchem Pharmaceutical Co., Ltd.
Contact:028-66825849
Address:chengdu
Pengchen New Material Technology Co., Ltd.
Contact:+86-512-63680537
Address:99.6 km of national road 318, Meiyan Community,Pingwang Town, Wujiang District, Suzhou 215225
Beijing Mesochem Technology Co.,LTD
website:http://www.mesochem.com
Contact:0086-10-57862036
Address:2301, Floor 23, Building 9 Lippo Plaza, Yard 8 Ronghua Middle Road, ETDZ, Beijing, China
Jiangsu Dacheng Pharmaceutical and Chemical Co.,Ltd
Contact:+86-0517-87036900
Address:Chuzhou Chemical park, Huai'an, Jiangsu Province
Doi:10.1016/S0040-4039(01)93467-7
(1989)Doi:10.1016/0040-4039(95)00672-Y
(1995)Doi:10.1002/adsc.201000719
(2011)Doi:10.1021/jm100991m
(2011)Doi:10.1002/cmdc.201000450
(2011)Doi:10.1016/j.carres.2010.11.026
(2011)