Quinazoline antifolate thymidylate synthase inhibitors: Replacement of glutamic acid in the C2-methyl series

DOI: 10.1021/jm00006a019

Source and publish data:

Journal of Medicinal Chemistry p. 994 - 1004 (1995)

Update date:2022-08-04

Topics:

Authors:

Marsham Marsham

Jackman Jackman

Barker Barker

Boyle Boyle

Pegg Pegg

Wardleworth

Kimbell Kimbell

O'Connor

Calvert Calvert

Hughes Hughes

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Article abstract of DOI:10.1021/jm00006a019

The synthesis of a series of analogues of the potent thymidylate synthase (TS) inhibitor N-[4[N-[(3,4-dihydro-2-methyl-4-oxo-6-quinazolinyl)methyl]-N- prop-2-ynylamino]benzoyl]-L-glutamic acid (ICI 198583, 1) is described in which the glutamic acid residu

Full text of DOI:10.1021/jm00006a019

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