Transformation of arenes into 3-arylpyrazoles and 3-arylisoxazolines with β-bromopropionyl chloride, hydrazine, and hydroxylamine

Article abstract of DOI:10.1016/j.tet.2019.130920

Successive treatment of arenes with β-bromopropionyl chloride and AlCl₃, followed by the reactions with hydrazines and Na₂CO₃, and then with MnO₂ gave the corresponding 3-arylpyrazoles in one pot in good to moderate yields. The same successive treatment of arenes with β-bromopropionyl chloride and AlCl₃, followed by the reactions with hydroxylamine and KF gave the corresponding 3-arylisoxazolines in one pot in good to moderate yields.