AN IMPROVED CYCLISATION PROTOCOL FOR THE SYNTHESIS OF δ,δ-DIFLUORO-δ-LACTONES

Article abstract of DOI:10.1016/S0022-1139(00)84152-4

An improved procedure for the synthesis of δ,δ-difluoro-δ-lactones from 5,5-difluoro-4-pentenoic acids is described.The method is illustrated for 2-benzyl-5,5-difluoro-4-pentenoic acid (2), which upon treatment with first mercury(II)acetate and then tri-n-butyltin hydride affords α-benzyl δ,δ-difluoro-δ-lactone (5).