
Journal of Fluorine Chemistry p. 273 - 276 (1989)
Update date:2022-08-04
Topics:
Kendrick, D. A.
Kolb, M.
An improved procedure for the synthesis of δ,δ-difluoro-δ-lactones from 5,5-difluoro-4-pentenoic acids is described.The method is illustrated for 2-benzyl-5,5-difluoro-4-pentenoic acid (2), which upon treatment with first mercury(II)acetate and then tri-n-butyltin hydride affords α-benzyl δ,δ-difluoro-δ-lactone (5).
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