SYNTHESIS OF α-AMINO-β-HYDROXY ACIDS USING KETENE BIS(TRIMETHYLSILYL) ACETAL OR ITS N-METHYL-N-TRIMETHYLSILYL ANALOG

Article abstract of DOI:10.1016/S0040-4039(00)83885-X

Condensation of the title compounds with aldehydes and ketones in the presence of trimethylsilyl triflate provided the correspondig α-amino-β-hydroxy acids in fair to good yields as a mixture of diastereomers.