Metal-Free C=C Double Bond Cleavage on Enaminones for the Synthesis of α-Ketoamides by Free-Radical Aerobic Oxygenation

DOI: 10.1002/ejoc.201900660

Source and publish data:

European Journal of Organic Chemistry p. 4422 - 4425 (2019)

Update date:2022-09-26

Topics:

Authors:

Yang, Yiming

Zhong, Guofeng

Fan, Junfen

Liu, Yunyun

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Article abstract of DOI:10.1002/ejoc.201900660

The tandem oxidation of the enaminone C=C double bond as well as subsequent C-N bond formation are realized under metal-free conditions by thermo-induced free radical transformation. In the presence of benzoyl peroxide (BPO) and N-iodosuccinimide (NIS), a

Full text of DOI:10.1002/ejoc.201900660

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