Mixed Copper, Zinc 2-Amino Benzylic Organometallics as Efficient Reagents for the Synthesis of Heterocycles

Article abstract of DOI:10.1016/S0040-4039(01)80510-4

The mixed copper, zinc benzylic organometallics 1a-1c react efficiently with various electrophiles.By the reaction with acylchlorides, highly functionalized 2-substituted indoles are produced.The treatment of 1a with allylic bromides, 3-iodo-cyclohexenone and ethyl propiolate furnishes polyfunctionalized anilines.Several of them could be converted into five or seven-membered heterocycles.