Reactions of Cyclic Oxalyl Compounds, Part 29: A Simple Synthesis of Functionalized 1H-Pyrimidines

Article abstract of DOI:10.1007/BF00808773

4-Benzoyl-5-phenylfuran-2,3-dione (1) and the semicarbazones 2, ureas and thioureas 6, respectively, combine with loss of water and carbondioxide yielding the 1H-pyrimidine derivatives 3 and 7, respectively, in moderate yields (30-75percent).Hydrolysis of 3b leads to the 1-amino-pyrimidine-2-one 4. - Keywords. 5-Benzoyl-1-methyleneamino-4-phenyl-1H-pyrimidine-2-ones; 1-Alkyl-5-benzoyl-4-phenyl-1H-pyrimidine-2-ones; 1,4,5-Substituted pyrimidine-2-thiones; Cyclocondensation reactions.