Steroids p. 460 - 463 (1992)
Update date:2022-08-06
Topics:
Kasal, Alexander
Hampl, Richard
Bicikova, Marie
Starka, Luboslav
On solvolysis of Westphalen-type steroids with a leaving group in the position 6β (e.g., 2), products of elimination (followed by rearrangement and fragmentation of the steroid skeleton) were prepared (e.g., 4 and 5).These products were subsequently converted to suitable analogs of the compound, which has been reported to promote hair growth (1).Compounds 11 to 13 exhibited strong antiandrogenic activity in vivo; however, this activity could not be interpreted either in terms of inhibition of 5α-reductase or by strong binding to an androgen receptor.Keywords: steroids with modified skeleton; androgen receptors; antiandrogens; 5α-reductase inhibitor; testosterone; dihydotestosterone
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