Angiotensin-converting enzyme inhibitors. 9. Novel [[N-(1-carboxy-3-phenylpropyl)amino]acyl]glycine derivatives with diuretic activity

DOI: 10.1021/jm00168a012

Source and publish data:

Journal of Medicinal Chemistry p. 1600 - 1606 (1990)

Update date:2022-09-26

Topics:

Authors:

Barton Barton

Piwinski

Skiles Skiles

Regan Regan

Menard Menard

Desai Desai

Golec Golec

Reilly Reilly

Goetzen Goetzen

Ueng Ueng

Warus Warus

Schwab Schwab

Samuels Samuels

Neiss Neiss

Suh Suh

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00168a012

A series of molecules 1 having sulfonamide diuretic moieties covalently linked to non-sulfhydryl angiotensin-converting enzyme inhibitors (ACEI) were prepared and tested for both activities. IC₅₀ values for ACEI as low as 7 nM were observed. Di

Full text of DOI:10.1021/jm00168a012

Products guided by the article

Product name:N-[7-(aminosulfonyl)-6-chlorospiro(2H-1,2,4-benzothiadiazine-3(4H),1'-cyclohexan)-4'-yl]-N-[N-(1-carboxy-3-phenylpropyl)-L-alanyl]lysine S,S-dioxide

Cas No:126849-60-3

R&D Labs maybe for 126849-60-3

Hangzhou LINGEBA Technology Co., Ltd.

Contact:+0086-571-87389059

Address:Office 1-913,NewYouth Plaza, GongShu Area, HangZhou,ZheJiang,P.R.China
NINGBO YINLIANG FOREIGN TRADE CO., LTD.

Contact:+86-574-87834016 / 87898057

Address:23F NO.666JINYU ROAD,YINGZHOU DISTRICT,NINGBO.CHINA
Shanghai Synmedia Chemical Co., Ltd

Contact:+86-21-38681880

Address:6th Floor, 11A Building, No.528 Ruiqing Road, Heqing town, Pudong new district, Shanghai China
Hebei Fulong Import & Export Co., Ltd.

Contact:86-311-87795661

Address:15A19 Zhongyuan Building,368 Youyi North Street,Shijiazhuang 050070,China
Antimex Chemical Limied

website:http://www.antimex.com

Contact:0086-21-50563169

Address:Room1027,No.Jinyu Road,Pudong

Relevant to this article

Nucleoside H-phosphonates. 12. Synthesis of nucleoside 3'-(hydrogen-phosphonothioate) monoesters via phosphinate intermediates

Doi:10.1021/jo00298a023
(1990)
Samarium diiodide mediated intramolecular cyclisation of mixed enone-enoate systems: A simple preparation of spirocyclic ethers

Doi:10.1016/j.tetlet.2010.12.077
(2011)
Azido-iodo-N-benzyl derivatives of threo-methylphenidate (Ritalin, Concerta): Rational design, synthesis, pharmacological evaluation, and dopamine transporter photoaffinity labeling

Doi:10.1016/j.bmc.2010.11.002
(2011)
Study of the conformationally flexible, wide bite-angle diphosphine 4,6-bis(3-diisopropylphosphinophenyl)dibenzofuran in rhodium(I) and palladium(II) coordination complexes

Doi:10.1021/ic102373w
(2011)
Phosphine-and nitrogen-containing lewis base catalyzed highly regioselective and geometric selective cyclization of isatin derived electron-deficient alkenes with ethyl 2,3-butadienoate

Doi:10.1021/ol1031798
(2011)
Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-α-hydroxylase/C17-20 lyase

Doi:10.1021/jm101120u
(2011)

Article Doi