Angiotensin-converting enzyme inhibitors. 9. Novel [[N-(1-carboxy-3-phenylpropyl)amino]acyl]glycine derivatives with diuretic activity

DOI: 10.1021/jm00168a012

Source and publish data:

Journal of Medicinal Chemistry p. 1600 - 1606 (1990)

Update date:2022-09-26

Topics:

Authors:

Barton Barton

Piwinski

Skiles Skiles

Regan Regan

Menard Menard

Desai Desai

Golec Golec

Reilly Reilly

Goetzen Goetzen

Ueng Ueng

Warus Warus

Schwab Schwab

Samuels Samuels

Neiss Neiss

Suh Suh

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00168a012

A series of molecules 1 having sulfonamide diuretic moieties covalently linked to non-sulfhydryl angiotensin-converting enzyme inhibitors (ACEI) were prepared and tested for both activities. IC₅₀ values for ACEI as low as 7 nM were observed. Di

Full text of DOI:10.1021/jm00168a012

Products guided by the article

Product name:N-[7-(aminosulfonyl)-6-chlorospiro(2H-1,2,4-benzothiadiazine-3(4H),1'-cyclohexan)-4'-yl]-N-[N-(1-carboxy-3-phenylpropyl)-L-alanyl]lysine S,S-dioxide

Cas No:126849-60-3

R&D Labs maybe for 126849-60-3

Amadis Chemical Co., Ltd.

website:http://www.amadischem.com

Contact:86-571-89925085

Address:Watts Cosine.No.166.Xiangmao Road.
Hangzhou utanpharma Co., Ltd

Contact:86-571-87758773

Address:Room604 ,6F, Block A1-3 Xixi Plaza,No. 588 Wenyi West RD, Hangzhou,310012, China
MINS GROUP CO.,LIMITED

Contact:18669908765

Address:Zibo City, Shandong Province, P.R.China
Mashilabs(shanghai)Co.,ltd

Contact:+86-21-54391580

Address:Room 502,No.65,Lane 2388 Hongxin Road,Shanghai,China
Zhejiang Chemicals Import & Export Corporation (ZHECHEM)

Contact:+86-571-87046953

Address:No. 37, Qingchun Road

Relevant to this article

Nucleoside H-phosphonates. 12. Synthesis of nucleoside 3'-(hydrogen-phosphonothioate) monoesters via phosphinate intermediates

Doi:10.1021/jo00298a023
(1990)
Samarium diiodide mediated intramolecular cyclisation of mixed enone-enoate systems: A simple preparation of spirocyclic ethers

Doi:10.1016/j.tetlet.2010.12.077
(2011)
Azido-iodo-N-benzyl derivatives of threo-methylphenidate (Ritalin, Concerta): Rational design, synthesis, pharmacological evaluation, and dopamine transporter photoaffinity labeling

Doi:10.1016/j.bmc.2010.11.002
(2011)
Study of the conformationally flexible, wide bite-angle diphosphine 4,6-bis(3-diisopropylphosphinophenyl)dibenzofuran in rhodium(I) and palladium(II) coordination complexes

Doi:10.1021/ic102373w
(2011)
Phosphine-and nitrogen-containing lewis base catalyzed highly regioselective and geometric selective cyclization of isatin derived electron-deficient alkenes with ethyl 2,3-butadienoate

Doi:10.1021/ol1031798
(2011)
Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-α-hydroxylase/C17-20 lyase

Doi:10.1021/jm101120u
(2011)

Article Doi