Angiotensin-converting enzyme inhibitors. 9. Novel [[N-(1-carboxy-3-phenylpropyl)amino]acyl]glycine derivatives with diuretic activity

DOI: 10.1021/jm00168a012

Source and publish data:

Journal of Medicinal Chemistry p. 1600 - 1606 (1990)

Update date:2022-09-26

Topics:

Authors:

Barton Barton

Piwinski

Skiles Skiles

Regan Regan

Menard Menard

Desai Desai

Golec Golec

Reilly Reilly

Goetzen Goetzen

Ueng Ueng

Warus Warus

Schwab Schwab

Samuels Samuels

Neiss Neiss

Suh Suh

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Article abstract of DOI:10.1021/jm00168a012

A series of molecules 1 having sulfonamide diuretic moieties covalently linked to non-sulfhydryl angiotensin-converting enzyme inhibitors (ACEI) were prepared and tested for both activities. IC₅₀ values for ACEI as low as 7 nM were observed. Di

Full text of DOI:10.1021/jm00168a012

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