SYNTHESIS OF 1,2,3,4,6,7,8,9-OCTAHYDROPYRIMIDOQUINOLINE-2,4-DIONE

Article abstract of DOI:10.1007/BF00479616

In the presence of hydrazine hydrate or sodium ethylate, ethyl 2-<(N-phenylcarbamoyl)amino>-5,6,7,8-tetrahydroquinoline-3-carboxylate is converted to 3-amino- or 3-phenyl-1,2,3,4,6,7,8,9-octahydropyrimido<4,5-b>quinoline-2,4-dione.Compounds analogous to the latter are also obtained during heating of 2-amino-5,6,7,8-tetrahydroquinoline-3-carboxylic arylamides with phenyl isocyanate of from their N-phenylcarbamoyl derivatives.