Intramolecular Addition of Carbon-Centered Tinthioimidoyl Radicals to Carbon-Carbon Double Bonds. Synthesis of γ- and δ-Thiolactams

DOI: 10.1021/jo00298a008

Source and publish data:

Journal of Organic Chemistry p. 3442 - 3444 (1990)

Update date:2022-08-05

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Authors:

Bachi, Mario D.

Denenmark, Daniella

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Article abstract of DOI:10.1021/jo00298a008

(Tri-n-butyltin)thioimidoyl radicals of type 6, which were efficiently generated by treatment of alk-3-enyl- and alk-4-enylisothiocyanates with tri-n-butyltin hydride and AIBN, underwent exo cyclization to give, after hydrolysis, the corresponding γ- or δ-thiolactams in good to excellent yields.

Full text of DOI:10.1021/jo00298a008

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