Synthesis of 3-fluorodiaminopimelic acid isomers as inhibitors of diaminopimelate epimerase: Stereocontrolled enzymatic elimination of hydrogen fluoride

DOI: 10.1021/ja00168a045

Source and publish data:

Journal of the American Chemical Society p. 4932 - 4942 (1990)

Update date:2022-07-30

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Authors:

Gelb, Michael H.

Lin, Yukang

Pickard, Michael A.

Song, Yonghong

Vederas, John C.

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Article abstract of DOI:10.1021/ja00168a045

Two hydroxylated and four fluorinated analogues of diaminopimelic acid (DAP) were synthesized in stereochemically pure form and examined for inhibition of diaminopimelate eimearase from Escherichia coli. The hydroxylated derivative of L.L-DAP, (2S,3R,6S)-

Full text of DOI:10.1021/ja00168a045

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