A NOVEL SYNTHESIS OF (3R,4R)-4-ACETOXY-3--2-AZETIDINONE, THE VERSATILE KEY INTERMEDIATE OF CARBAPENEM SYNTHESIS, FROM (S)-ETHYL LACTATE

Article abstract of DOI:10.1016/S0040-4039(00)85317-4

A highly efficient synthesis of the title compound was accomplished employing the addition of diketene to chiral imine as a key stereoselective reaction and using inexpensive (S)-ethyl lactate as a starting material.