Synthesis of Cyclopentanobenzanthracene Compounds Related to Carcinogenic Benzanthracene and Cholanthrene Hydrocarbons

Article abstract of DOI:10.1021/jo00299a018

Syntheses of benzaceanthrylene (4a), 8-methylbenzaceanthrylene (4b), and their 1,2-dihydro derivatives (3a,b), as well as 6-methylbenzaceanthrylene (5a) and its 1,2-dihydro derivative (2b) from benzanthracene-7,12-dione are described.Compounds 2b, 3b, 4b, and 5b, all of which contain a methyl group in nonbenzo bay region position, are predicted to be relatively potent carcinogens.