The Synthesis of Substituted Lactones by Intramolecular Chirality Transfer with Stereodifferentiating Chiral α-Ester Radical Intermediates

Article abstract of DOI:10.1021/jo00298a005

Carbon radicals generated from α-halo acetate, propionate, and related allylic and homoallylic esters can cyclize onto activated and unactivated olefins to give α,β-substituted lactones with good to excellent stereochemical control in yields ranging from 52 to 90percent.