Bioorganic and Medicinal Chemistry Letters p. 1840 - 1847 (2017)
Update date:2022-08-03
Topics:
Kirschberg, Thorsten A.
Metobo, Sammy
Clarke, Michael O.
Aktoudianakis, Vangelis
Babusis, Darius
Barauskas, Ona
Birkus, Gabriel
Butler, Thomas
Byun, Daniel
Chin, Gregory
Doerffler, Edward
Edwards, Thomas E.
Fenaux, Martijn
Lee, Rick
Lew, Willard
Mish, Michael R.
Murakami, Eisuke
Park, Yeojin
Squires, Neil H.
Tirunagari, Neeraj
Wang, Ting
Whitcomb, Mark
Xu, Jie
Yang, Huiling
Ye, Hong
Zhang, Lijun
Appleby, Todd C.
Feng, Joy Y.
Ray, Adrian S.
Cho, Aesop
Kim, Choung U.
A series of 2′-fluorinated C-nucleosides were prepared and tested for anti-HCV activity. Among them, the triphosphate of 2′-fluoro-2′-C-methyl adenosine C-nucleoside (15) was a potent and selective inhibitor of the NS5B polymerase and maintained activity
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