Enzymes as synthetic catalysts: Mechanistic and active-site considerations of natural and modified chymotrypsin

Article abstract of DOI:10.1021/ja00169a043

This paper describes the mechanistic investigation of α-chymotrypsin and [Met₁₉₂-sulfoxide]-α-chymotrypsin-catalyzed peptide synthesis in a kinetically controlled process (i.e., aminolysis) and the relative stabilities of both enzymes in differ