ASYMMETRIC ALKYLATION OF N-ACYLSULTAMS: A GENERAL ROUTE TO ENANTIOMERICALLY PURE, CRYSTALLINE C(α,α)-DISUBSTITUTED CARBOXYLIC ACID DERIVATIVES.

Article abstract of DOI:10.1016/S0040-4039(01)93810-9

Successive treatment of acylsultams 2 with nBuLi or NHMDS and primary alkyl halides, followed by crystallization, gave pure C(α)-alkylation products 4 and, via their non-destructive cleavage, enantiomerically pure alcohols 5 or carboxylic acids 6.