ASYMMETRIC ALKYLATION OF N-ACYLSULTAMS: A GENERAL ROUTE TO ENANTIOMERICALLY PURE, CRYSTALLINE C(α,α)-DISUBSTITUTED CARBOXYLIC ACID DERIVATIVES.

DOI: 10.1016/S0040-4039(01)93810-9

Source and publish data:

Tetrahedron Letters p. 5603 - 5606 (1989)

Update date:2022-08-04

Topics:

Authors:

Oppolzer, Wolfgang

Moretti, Robert

Thomi, Silvia

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Article abstract of DOI:10.1016/S0040-4039(01)93810-9

Successive treatment of acylsultams 2 with nBuLi or NHMDS and primary alkyl halides, followed by crystallization, gave pure C(α)-alkylation products 4 and, via their non-destructive cleavage, enantiomerically pure alcohols 5 or carboxylic acids 6.

Full text of DOI:10.1016/S0040-4039(01)93810-9

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