Rhodium-catalyzed direct alkylation of benzylic amines using alkyl bromides

Article abstract of DOI:10.1007/s00706-018-2305-9

Within this contribution, the development and substrate scope evaluation of a direct alkylation protocol of the C(sp³)–H bond of benzylic amines using alkyl bromides is reported. This pyridine-directed method is initiated by elimination of the alkyl bromide to a terminal olefin, which is then the true alkylating agent. Graphical abstract: [Figure not available: see fulltext.].