Metal-complexing, DNA-binding and DNA-cleaving properties of a synthetic molecule AMBIGLU, a simplified model for the study of bleomycin

Article abstract of DOI:10.1016/0223-5234(89)90080-9

On the basis of the previous studies on simple synthetic molecules structurally related to the anti-tumor drug bleomycin-A2 (BLM-A2), the roles of the main parts of the parent compound, a metal-chelating peptide, a DNA-binding heterocycle and a protecting