Journal of the American Chemical Society
COMMUNICATION
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In conclusion, we have developed a new catalytic method for
the straightforward hydrogenation of carboxamides and esters.
Our method using chiral ligands will be particularly useful when
stereochemically well-defined 2-substituted alcohols are required
despite the lack of any convenient access to stereochemically
well-defined 2-substituted esters. Exploration of suitable chiral
catalyst systems that meet this purpose is now in progress in our
laboratories.
’ ASSOCIATED CONTENT
S
Supporting Information. Experimental procedures and
b
X-ray crystallographic data for 4d (CIF). This material is avail-
’ AUTHOR INFORMATION
Corresponding Author
Present Addresses
†Institute for Materials Chemistry and Engineering (IMCE),
Kyushu University, Kasuga, Fukuoka 816-8580, Japan.
(10) Ito, M.; Hirakawa, M.; Osaku, A.; Ikariya, T. Organometallics
2001, 20, 379–381.
’ ACKNOWLEDGMENT
This research was financially supported by the MEXT
(18065007, 21550096, and 22225004) and partly supported by
the GCOE Program and the Asahi Glass Foundation (M.I.).
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