Journal of Medicinal Chemistry p. 1898 - 1905 (1990)
Update date:2022-09-26
Topics:
Fujita, Masanobu
Ito, Susumu
Ota, Atsutoshi
Kato, Nobuharu
Yamamoto, Koji
et al.
As an extension of the previous investigation (J.Med.Chem. 1988, 31, 919), we synthesized a series of 2-<2-<(aminoalkyl)oxy>5-methoxyphenyl>-3,4-dihydro-4-methyl-3-oxo-2H-1,4-benzothiazines (3) and evaluated their Ca2+ antagonistic activities.Ca2+ antagonistic activity was measured with isolated depolarized guinea pig taenia cecum.On the basis of their potent Ca2+ antagonistic activity, six benzothiazines were selected and further evaluated for their vasocardioselectivity.Among these six compounds, the key compound 15 <3,4-dihydro-2-<5-methoxy-2-<3-
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