Synthesis, anti-hypertensive and β-adrenoreceptor antagonist activities of 3--phenyl>-4(3H) quinazolones

DOI: 10.1016/0223-5234(89)90025-1

Source and publish data:

European Journal of Medicinal Chemistry p. 585 - 590 (1989)

Update date:2022-08-03

Topics:

Authors:

Botros, Samir

Saad, Samir F.

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Article abstract of DOI:10.1016/0223-5234(89)90025-1

The synthesis of seven 2-substituted 3-<4-aryl-1-piperazinyl )-isopropanoloxy>-phenyl>-4(3H)quinazolones is described.Pharmacological tests showed that some of the synthesized compounds (3a-c and 3e) possessed pronounced and sustained hypotensive effects,

Full text of DOI:10.1016/0223-5234(89)90025-1

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