Synthesis and evaluation of 1,2,2-tris(sulfonyl)hydrazines as antineoplastic and trypanocidal agents

DOI: 10.1021/jm00170a033

Source and publish data:

Journal of Medicinal Chemistry p. 2259 - 2264 (1990)

Update date:2022-08-04

Topics:

Authors:

Shyam Shyam

Penketh Penketh

Divo Divo

Loomis Loomis

Patton Patton

Sartorelli

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Article abstract of DOI:10.1021/jm00170a033

Several 1,2,2-tris(sulfonyl)hydrazines, conceived as prodrugs of 1,2-bis(sulfonyl)hydrazines, were synthesized and evaluated for antineoplastic and trypanocidal activities in mice. 1-Methyl-1,2,2-tris(methylsulfonyl)hydrazine emerged as an extremely effic

Full text of DOI:10.1021/jm00170a033

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