Synthesis and evaluation of 1,2,2-tris(sulfonyl)hydrazines as antineoplastic and trypanocidal agents

DOI: 10.1021/jm00170a033

Source and publish data:

Journal of Medicinal Chemistry p. 2259 - 2264 (1990)

Update date:2022-08-04

Topics:

Authors:

Shyam Shyam

Penketh Penketh

Divo Divo

Loomis Loomis

Patton Patton

Sartorelli

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00170a033

Several 1,2,2-tris(sulfonyl)hydrazines, conceived as prodrugs of 1,2-bis(sulfonyl)hydrazines, were synthesized and evaluated for antineoplastic and trypanocidal activities in mice. 1-Methyl-1,2,2-tris(methylsulfonyl)hydrazine emerged as an extremely effic

Full text of DOI:10.1021/jm00170a033

Products guided by the article

Product name:1-methyl-1,2,2-tris(methylsulfonyl)hydrazine

Cas No:127792-83-0

R&D Labs maybe for 127792-83-0

Hubei Lansun Biochemical Pharmaceutical Co., Ltd

Contact:714-6395977

Address:No. 81 Pengcheng Avenue, economic and technological development zone, Huangshi City, Hubei Province,China
Zhejiang kehong chemical co., ltd

Contact:0086-575-85522000

Address:xiner center RD binhai industrial zone shaoxing zhejiang province P.R.China,312073
KindChem Co.,Ltd,

Contact:+86-25-85281586

Address:13F,Bld2#,South of Longpan Road
Jinan Hongfangde Pharmatech Co.,Ltd

Contact:86-531-88870908

Address:F Bldg. West Unit North Area of Univ. Tech. Garden Xinyu Rd. Jinan New & High Tech Industry Development Zone Shandong, China
WUHU HUAHAI BIOLOGY ENGINEERING CO LTD

Contact:+86-553-3836920

Address:7/F NO.82 LAODONG ROAD WUHU CHINA

Relevant to this article

Tandem Cope-Claisen Rearrangements for the Construction of (E,E)-1,6-Cyclodecadienes. Effect of Ketene Acetal Substituents on ΔG<*>_Claisen

Doi:10.1021/ja00397a053
(1981)
Enantioselective conjugate silyl additions to α,β-unsaturated aldehydes catalyzed by combination of transition metal and chiral amine catalysts

Doi:10.1002/adsc.201000908
(2011)
Ligand modifications modulate the mechanism of binuclear phosphatase biomimetics

Doi:10.1016/j.poly.2012.06.008
(2013)
Searching for Dual Inhibitors of the MDM2-p53 and MDMX-p53 Protein-Protein Interaction by a Scaffold-Hopping Approach

Doi:10.1111/cbdd.12474
(2015)
A highly regioselective, protecting group controlled, synthesis of bicyclic compounds via Pd-catalysed intramolecular cyclisations

Doi:10.1016/j.tetlet.2013.02.068
(2013)
Synthesis, crystal structures and theoretical calculations of new 1-[2-(5-chloro-2-benzoxazolinone-3-yl)acetyl]-3,5-diphenyl-4,5-dihydro-(1H) -pyrazoles

Doi:10.1016/j.molstruc.2013.01.066
(2013)

Article Doi