Triple asymmetric synthesis for fragment assembly: Validity of approximate multiplicativity of the three diastereofacial selectivities

Article abstract of DOI:10.1016/S0040-4039(00)70696-4

A strategy of triple asymmetric synthesis is illustrated to be effective for stereochemical control in fragment assembly, a task often encountered in convergent natural product synthesis. The stereochemical outcome of aldol reactions involving three chiral components supports a rule of approximate multiplicativity of facial selectivities intrinsic to the chiral reactants involved in each reaction.