AN EFFICIENT METHOD FOR HYDROLYSIS OF N-MONOSUBSTITUTED AMIDES VIA ACETOXYPIVALIMIDES

DOI: 10.1016/S0040-4039(00)94615-X

Source and publish data:

Tetrahedron Letters p. 731 - 734 (1990)

Update date:2022-08-04

Topics:

Authors:

Tsunoda, Tetsuto

Sasaki, Osamu

Ito, Sho

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Article abstract of DOI:10.1016/S0040-4039(00)94615-X

Various N-monosubstituted carboxamides were efficiently hydrolyzed in two steps through acetoxypivalimides.The method can be applied to a wide range of amides without racemization of α-position of the acyl groups.The amines can also be recovered.

Full text of DOI:10.1016/S0040-4039(00)94615-X

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